First, the ICD + group showed reduced “continue-to-gamble” activity in right inferior frontal gyrus and subthalamic nucleus. These patients did not differ in risk-taking attitude during sequential gambling from 13 patients without impulse control disorder (ICD - group), but they displayed differences in gambling-related activity in cortico-subcortical brain areas supporting inhibitory control. 13 patients had an impulse control disorder (ICD + group). During a gambling round, patients repeatedly decided between the option to continue with gambling and accumulate more monetary reward under increasing risk or the option to bank the current balance and start a new round. Patients performed a sequential gambling task while being ON and OFF their regular dopaminergic treatment. To address this question, we mapped task-related brain activity with whole-brain functional magnetic resonance imaging at 3 Tesla in 26 patients with Parkinson’s disease. It is unclear how dopaminergic medication affects the neural networks that contribute to withholding inappropriate actions. ![]() Dopaminergic treatment may impair the ability to suppress impulsive behaviours in patients with Parkinson's disease, triggering impulse control disorders.
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